valium half life elderly
However benzodiazepines have been found to be frequently implicated in drug-associated hospital admissions. Half-life values from the multiple-dose study were closely correlated with values from previous single-dose studies of diazepam R 2 085 and DMDZ R 2 094 in the same subjects.
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Doctors use the term half-life to describe how long your body takes to eliminate half.
. The elderly metabolize benzodiazepines less efficiently and they may be unable to tolerate longer half life medications. Once diazepam breaks down into these substances they can be eliminated from the. Thirty percent of all prescription drugs are prescribed for elderly persons and many of these medications are psychotropics Of the available sedative.
To determine how long the chemical diazepam within Valium stays in your system after stopping it is necessary to review its elimination half-life. Prevalence of use. Oxazepam has a half-life of 4-15 hours while temazepam has a half-life of 8-22 hours.
Furthermore alterations in phar. Diazepam accumulates upon multiple dosing and the terminal elimination half-life is slightly prolonged. This is best illustrated by a definitive study with.
Many of the studies carried out using drug plasma half-life and clearance assessments are complicated by changes in distribution. In children 3 - 8 years old the mean half-life of diazepam has been reported to be 18 hours. Ashton states that benzodiazepines without active metabolites are.
The elimination half-life of. Longer half-lives such as chlor-diazepoxide diazepam and flu-razepam are more likely to accumu-late in the body and cause prolonged sedation 10. In children 3 - 8 years old the mean half-life of diazepam has been reported to be 18 hours.
There is suggestive evidence that benzodiazepines especially. While benzodiazepine treatment is known to increase the risk of hip fracture in older populations controversy persists over which characteristics of benzodiazepine use eg. In full term infants elimination half-lives around 30 hours have been reported with.
In full term infants elimination half-lives around 30 hours have been reported with. However Valium is a long-lasting benzodiazepine so it stays in your body for much longer.
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